The major allele of ApoE SNP rs429358 is the T allele. The minor (C) allele is associated with an increased risk for developing Alzheimer's disease, where the risk increases in a dose-dependent manner, particularly in combination with the rs7412(C) allele on the same chromosome.
GeneTAG Technology offers a dual-iDDS probe SNP genotyping assay for both the C and T alleles of rs429358. Representative results are shown below.
The local sequence environment of the C/T polymorphism in factor II makes it difficult distinguish between these targets. Our dual-iDDS probe factor II assay uses two different antiprobes to increase the detection specificity.